TGFβ attenuates tumour response to PD-L1 blockade by contributing to
exclusion of T cells

TGFβ attenuates tumour response to PD-L1 blockade by contributing to
exclusion of T cells, Published online: 14 February 2018; doi:10.1038/nature25501

In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling. http://feeds.nature.com/nature/rss/current via https://www.nature.com/articles/nature25501

Advertisements